Drug manuals
Phentolamine
Phentolamine Drug Phentolamine Brand names Oraverse ®, Rogitine ® Indications Hypertensive crisis. Mechanism of action Phentolamine is a non-selective alpha-adrenergic blocker.…
Phentolamine
| Drug | Phentolamine |
| Brand names | Oraverse ®, Rogitine ® |
| Indications | Hypertensive crisis. |
| Mechanism of action | Phentolamine is a non-selective alpha-adrenergic blocker. Phentolamine reduces blood pressure while increasing catecholamine activity. |
| Effects | Primarily causes afterload reduction. |
| Time to onset of action | 1 to 2 minutes |
| Duration of action | 10 to 30 minutes |
| Delivery | IV |
| Dose | Bolus injection: 5 to 15 mg every 5 to 15 minutes as necessary. Continuous infusion: Start infusion at 0.1 mg/min and increase in increments of 0.1 mg. |
| Adverse effects | Tachycardia. Flushing. Headache. Nausea. Vomiting. |
| Caution | Rarely used unless patient has a confirmed diagnosis of pheochromocytoma Treatment of hypertension associated with pheochromocytoma; treatment of dermal necrosis after extravasation of drugs with á-adrenergic effects. |
Phentolamine doses and administration in hypertension (hypertensive crisis/emergency).
Nitroprusside
Nitroprusside Drug Nitroprusside Brand names Nipride ®, Nipride RTU ®, Nitropress ®. Indications Pulmonary edema, congestive heart failure. Angina pectoris. Hypertension,…
Hydralazine
Hydralazine Hydralazine is not preferred for hypertensive emergencies due to the high risk of reflex sympathetic stimulation. Drug Hydralazine Brand names Apresoline ®, Bidil ®…