Drug manuals
Esmolol
Esmolol Drug Esmolol Brand names Brevibloc ® Indications Short-term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive…
Esmolol
| Drug | Esmolol |
| Brand names | Brevibloc ® |
| Indications | Short-term control of ventricular rate (including perioperative tachycardia) and hypertension (including hypertensive emergency, perioperative hypertension). |
| Mechanism of action | • Relatively cardioselective (beta-1 receptor blocker) beta-blocker with ultra-short acting effect. • Half-life: 9 minutes. |
| Effects | • Esmolol is a beta-adrenergic receptor blocker. • Esmolol lowers blood pressure immediately (within 1 minute) • Esmolol may also be used to control supraventricular tachycardia (rate control). • Esmolol may be used to reduce myocardial ischemia in the CCU or ICU. |
| Time to onset of action | 1 minute |
| Duration of action | 20-30 minutes |
| Delivery | IV |
| Dose | Loading dose: 500 μg/kg bolus over 1 minute. Infusion start dose: 25–50 μg/kg/min. Maximum infusion dose: 300 μg/kg/min. Bolus doses of 300 μg/kg can be repeated during infusion. |
| Adverse effects | Flushing. Nausea. Bronchospasm. AV-block. |
| Caution | • Avoid in acute heart failure. • May cause bradycardia. |
Esmolol doses and administration in hypertension and tachycardia.
Enalaprilat
Enalaprilat Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect. Drug…
Labetalol
Labetalol Drug Labetalol Brand names Trandate ® Indications Mycoardial ischemia. Hypertension. Hypertensive emergency, including in pregnancy. Postoperative hypertension.…