Drug manuals
Nicardipine
Nicardipine Drug Nicardipine Brand names Cardene ® Indications Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina…
Nicardipine
| Drug | Nicardipine |
| Brand names | Cardene ® |
| Indications | Hypertension, hypertensive emergency/crisis. Pregnancy induced hypertension. Angina pectoris Prinzmetal's angina |
| Mechanism of action | Nicardipine is a dihydropyridine calcium-channel blocker (CCB). Nicardipine inhibits the influx of extracellular calcium in the myocardial and peripheral vascular smooth muscle cell membranes, thus inhibiting the contraction of smooth muscle cells. As compared with nitroprusside, nicardipine induces relatively greater venodilation than arteriolar dilation. |
| Effects | Nicardipine causes dilation of the coronary and systemic arteries, decreases total peripheral resistance, decreases systemic blood pressure, and decreases afterload. Nicardipine has antianginal and antihypertensive effects. |
| Time to onset of action | 5 to 15 minutes |
| Duration of action | 1.5 to 5 hours |
| Delivery | IV |
| Dose | 5–15 mg/hour IV infusion. Higher doses (up to 30 mg/hour) may be required in some patients. |
| Adverse effects | Tachycardia. Headache. Flushing. Edema. Dizziness. |
| Caution | Should be used cautiously in patients with myocardial ischemia and/or heart failure. |
Nicardipine doses and administration in hypertension (hypertensive crisis/emergency).
Clevidipine
Clevidipine Drug Clevidipine Brand names Cleviprex ® Indications Hypertension and hypertensive emergency. Treatment of postoperative hypertension. Mechanism of action Ultra-short…
Enalaprilat
Enalaprilat Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect. Drug…