Enalaprilat
Enalaprilat Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect. Drug…
Enalaprilat
Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect.
| Drug | Enalaprilat |
| Brand names | Vasotec IV ® |
| Indications | Hypertension and hypertensive emergency. Acute left ventricular failure. |
| Mechanism of action | Enalaprilat is the active metabolite (ester) of enalapril, an angiotensin-converting enzyme (ACE) inhibitor. Enalaprilat lowers blood pressure by inhibiting ACE. |
| Effects | • The hypotensive effect of enalaprilat depends on plasma volume and plasma renin activity. Volume depletion and high plasma renin activity increase the effect of enalaprilat, and may cause severe hypotension. |
| Time to onset of action | 15 to 30 minutes. |
| Peak effect | Within hours. |
| Duration of effect | 8 to 24 hours |
| Delivery | IV |
| Dose | Initial dose: 1.25 mg iv. Increase as necessary. Maximum dose: 5 mg iv every six hours. |
| Adverse effects | Severe hypotension. |
| Contraindications | • Contraindicated in pregnancy, severe renal artery stenosis, severe hyperkalemia. • Avoid in acute heart failure and acute myocardial infarction. |
Enalaprilat doses and administration in hypertension.
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