Enalaprilat

Enalaprilat is rarely used in hypertensive crisis due to its slow onset, prolonged duration of effect, and significant individual variations in its effect.


Drug	Enalaprilat
Brand names	Vasotec IV ®
Indications	Hypertension and hypertensive emergency. Acute left ventricular failure.
Mechanism of action	Enalaprilat is the active metabolite (ester) of enalapril, an angiotensin-converting enzyme (ACE) inhibitor. Enalaprilat lowers blood pressure by inhibiting ACE.
Effects	• The hypotensive effect of enalaprilat depends on plasma volume and plasma renin activity. Volume depletion and high plasma renin activity increase the effect of enalaprilat, and may cause severe hypotension.
Time to onset of action	15 to 30 minutes.
Peak effect	Within hours.
Duration of effect	8 to 24 hours
Delivery	IV
Dose	Initial dose: 1.25 mg iv. Increase as necessary. Maximum dose: 5 mg iv every six hours.
Adverse effects	Severe hypotension.
Contraindications	• Contraindicated in pregnancy, severe renal artery stenosis, severe hyperkalemia. • Avoid in acute heart failure and acute myocardial infarction.

Enalaprilat doses and administration in hypertension.

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Enalaprilat

Enalaprilat

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