The Cardiovascular
Drug manuals

Fenoldopam

Fenoldopam Drug Fenoldopam Brand names Corlopam ® Indications Short term management of hypertension, including hypertensive emergency. Mechanism of action • Systemic Dopamine-1…

Fenoldopam

DrugFenoldopam
Brand namesCorlopam ®
IndicationsShort term management of hypertension, including hypertensive emergency.
Mechanism of action• Systemic Dopamine-1 (D1) receptor agonist. • Lowers blood pressure while maintaining or increasing kidney perfusion.
EffectsDopamine-1 receptor agonists lower systemic blood pressure and increase renal perfusion.
Time to onset of action50 to 10 minutes
Duration of action30 to 60 minutes
DeliveryIV
DoseInitial infusion dose: 0.1 μg/kg/minute iv. Titrated at 15 minutes intervals. Maximum infusion dose: 1.6 μg/kg/minute
Adverse effectsHeadache. Flushing. Tachycardia. Nausea. Hypokalemia. Increased intra-ocular pressure in patients with glaucoma.
CautionUsed cautiously in patients with glaucoma or increased intracranial pressure.

Fenoldopam doses and administration in hypertension.

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