Cardiovascular Medicine

Calculate CHADS-VASc Score and evaluate indication for anticoagulation

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Calculate CHADS-VASc Score and evaluate indication for anticoagulation

CHA2DS2-VASc Score Calculator

Interpretation of CHADS-VASc score and decisions on anticoagulation

MenWomen
PointsRecommendationEvidenceRecommendationEvidence
0No treatmentLowNo treatmentHigh
1Oral anticoagulation (warfarin or NOAK1 is considered for male patients with a score of 1 or more. Patient preference and risk-benefit balance determine whether treatment is initiated.HighNo treatmentHigh
2Oral anticoagulation (warfarin or NOAC) is recommended for all male patients with scores of 2 or more.Very highOral anticoagulation (warfarin or NOACs is considered for female patients with scores of 2 or more. Patient preference and the balance of risk and benefit determine whether treatment is initiated.High
3-9As above.Very highOral anticoagulation (warfarin or NOAC) is recommended for all female patients with a score of 3 or more.Very high
1NOAC = novel oral anticoagulants (new oral anticoagulants) include apixaban (Eliquis®), dabigatran (Pradaxa®), edoxaban (Lixiana®), rivaroxaban (Xarelto®).
If oral anticoagulation is indicated, NOACs should be chosen except in patients with moderate to severe mitral stenosis or mechanical heart valves; for these patients, warfarin is chosen instead (Class 1 B recommendation).

There are several models for risk-stratifying patients with atrial fibrillation, and CHADS-VASc is currently the most widely used model. The aim of CHADS-VASc is to identify patients at high risk of stroke, TIA or systemic thromboembolism and initiate treatment with anticoagulants (rarely with antiplatelet agents). CHADS-VASc predicts the risk of thromboembolism (stroke, TIA, systemic thromboembolism) in the next 12 months and the calculations apply to untreated patients with non-valvular atrial fibrillation (Table 1).

CHADS-VASc ScoreRisk of ischemic strokeRisk för stroke/TIA/systemisk tromboembolism
00.2%0.3%
10.6%0.9%
22.2%2.9%
33.2%4.6%
44.8%6.7%
57.2%10.0%
69.7%13.6%
711.2%15.7%
810.8%15.2%
912.2%17.4%

CHADS-Vasc score

  • C: Congestive heart failure (1 point)
  • H: Hypertension (1 point)
  • A: Age 75 and older (2 points)
  • D: Diabetes Mellitus (1 point)
  • S: Prior Stroke or TIA or thromboembolism (2 points)
  • V: Vascular disease (1 point)
  • A: Age 65 to 74 years (1 point)
  • Sc: Sex category: being female (1 point)

In clinical trials (see References), patients with non-valvular atrial fibrillation and a CHADS-VASc score of 0 have had a very low incidence of thromboembolic events, therefore withholding treatment should be considered. Among patients who are updated for anticoagulation, bleeding risk should be calculated using risk models such as ATRIA or HAS-BLED. There is at best weak support that acetylsalicylic acid (ASA) can be used as monotherapy (this means that acetylsalicylic acid should not, as a rule, be used for stroke prevention in patients with atrial fibrillation).

References

Lip GY, Nieuwlaat R, Pisters R, Lane DA, Crijns HJ. Refining clinical risk stratification for predicting stroke and thromboembolism in atrial fibrillation using a novel risk factor-based approach: the euro heart survey on atrial fibrillation. Chest. 2010 Feb;137(2):263-72. doi: 10.1378/chest.09-1584. Epub 2009 Sep 17. PubMed PMID: 19762550.

Ntaios G, et al. CHADS2, CHA2DS2-VASc, and long-term stroke outcome in patients without atrial fibrillation. March 12, 2013 80:1009-1017; published ahead of print February 13, 2013

Friberg L, Rosenqvist M, Lip GY. Evaluation of risk stratification schemes for ischaemic stroke and bleeding in 182 678 patients with atrial fibrillation: the Swedish Atrial Fibrillation cohort study. Eur Heart J. 2012 Jun;33(12):1500-10. doi: 10.1093/eurheartj/ehr488. Epub 2012 Jan 13. PubMed PMID: 22246443.

Okumura K, Inoue H, Atarashi H, Yamashita T, Tomita H, Origasa H; J-RHYTHM Registry Investigators.Validation of CHA₂DS₂-VASc and HAS-BLED scores in Japanese patients with nonvalvular atrial fibrillation: an analysis of the J-RHYTHM Registry. Circ J. 2014;78(7):1593-9. Epub 2014 Apr 22.

Camm AJ, Lip GY, De Caterina R, Savelieva I, Atar D, Hohnloser SH, Hindricks G, Kirchhof P; ESC Committee for Practice Guidelines (CPG). 2012 focused update of the ESC Guidelines for the management of atrial fibrillation: an update of the 2010 ESC Guidelines for the management of atrial fibrillation. Developed with the special contribution of the European Heart Rhythm Association. Eur Heart J. 2012 Nov;33(21):2719-47. doi: 10.1093/eurheartj/ehs253. Epub 2012 Aug 24. Erratum in: Eur Heart J. 2013 Mar;34(10):790. Eur Heart J. 2013 Sep;34(36):2850-1. PubMed PMID: 22922413.

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