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West Haven criteria for hepatic encephalopathy

Grades severity of overt hepatic encephalopathy.

West Haven criteria for hepatic encephalopathy
Mental state and neuromuscular findings
ResultGrade 0

No clinically apparent encephalopathy (grade 0). Changes, if any, are detectable only on psychometric or neurophysiological testing (minimal / covert HE).

Classification
Covert / minimal HE

When to use

  • Grading and tracking the severity of hepatic encephalopathy in patients with cirrhosis or acute liver failure.
  • Grades 2 and above define overt encephalopathy under the 2014 AASLD/EASL classification.

Formula

Single ordinal grade 0-4 assigned from the highest-severity mental-state and neuromuscular findings observed. Grade 0-1 = covert; grade 2-4 = overt.

Pearls and pitfalls

  • Asterixis is characteristic of grades 1-3 but disappears in deep coma (grade 4).
  • Always search for a precipitant (infection, GI bleed, constipation, electrolyte disturbance, sedatives).

References

  1. Conn HO, et al. Gastroenterology. 1977;72(4 Pt 1):573-83.
  2. Vilstrup H, et al. Hepatology. 2014;60(2):715-35.