The Cardiovascular
ToolsCalculators

tPA (Alteplase) Dosing for Ischemic Stroke Calculator

Weight-based alteplase dose, bolus, and infusion for acute ischemic stroke.

tPA (Alteplase) Dosing for Ischemic Stroke Calculator
Weight
Complete the fields above to see the result.

When to use

  • Dosing IV alteplase for acute ischemic stroke within the approved treatment window.

Formula

Total dose = 0.9 mg/kg IV, maximum 90 mg; 10% as bolus over 1 minute, remaining 90% infused over 60 minutes.

Pearls and pitfalls

  • Dosing regimen differs from the acute MI alteplase protocol - do not interchange.
  • Confirm eligibility (window, contraindications, blood pressure control) before dosing.

References

  1. National Institute of Neurological Disorders and Stroke rt-PA Stroke Study Group. N Engl J Med. 1995;333(24):1581-7.