ToolsCalculators
Rome IV Diagnostic Criteria for Globus
Symptom-based diagnosis of a persistent lump-in-the-throat sensation.
Rome IV Diagnostic Criteria for Globus
Persistent or intermittent, nonpainful sensation of a lump or foreign body in the throat
Sensation occurs between meals (i.e., not only while swallowing)
No dysphagia or odynophagia
No evidence that gastroesophageal reflux is the cause
No evidence that eosinophilic esophagitis is the cause
No major esophageal motor disorder as the cause
Onset ≥6 months ago, with criteria fulfilled for the last 3 months
ResultCriteria not met
Does not meet Rome IV criteria for globus; reconsider GERD, eosinophilic esophagitis, a motor disorder, or a structural ENT lesion.
When to use
- Persistent nonpainful throat-lump sensation occurring between meals, once structural and reflux-related causes have been excluded.
Formula
Diagnosis requires all of: nonpainful lump/foreign-body sensation in the throat; occurs between meals; no dysphagia or odynophagia; GERD excluded; eosinophilic esophagitis excluded; no major esophageal motor disorder; onset ≥6 months before diagnosis with criteria met for the last 3 months.
Pearls and pitfalls
- Presence of dysphagia or odynophagia should prompt evaluation for a structural cause rather than a diagnosis of globus.