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Rai Staging System for Chronic Lymphocytic Leukemia (CLL)

Rai Staging System for Chronic Lymphocytic Leukemia (CLL)
Lymphadenopathy present
Any palpable lymph node group >=1 cm.
Hepatomegaly and/or splenomegaly
Anemia (hemoglobin <11 g/dL)
Thrombocytopenia (platelets <100 x10⁹/L)
ResultRai stage 0

Modified risk group: low risk.

Stage
0
Risk group
Low

When to use

  • Clinical staging of CLL at diagnosis (assumes lymphocytosis with or without bone marrow lymphocytic infiltration is already established).

Formula

Stage 0: lymphocytosis only. Stage I: + lymphadenopathy. Stage II: + hepato/splenomegaly. Stage III: + anemia. Stage IV: + thrombocytopenia. Highest applicable feature determines stage; modified risk groups: low (0), intermediate (I-II), high (III-IV).

References

  1. Rai KR, et al. Blood. 1975;46(2):219-234.