ToolsCalculators
Peripheral Blood Stem Cell Collection (CD34+ Yield)
Predicted CD34+ cell yield per kilogram from a leukapheresis procedure.
Peripheral Blood Stem Cell Collection (CD34+ Yield)
Pre-apheresis peripheral blood CD34+ count
cells/uL
Blood volume to be processed
L
Patient weight
Collection efficiency
Fraction of the CD34+ cells passing through the separator that are actually collected; typically 40-70%.
%
Complete the fields above to see the result.
When to use
- Planning apheresis volume/duration and predicting whether a collection will meet transplant-dose targets.
Formula
Predicted yield (x10^6 CD34+ cells/kg) = pre-apheresis CD34+ count (cells/uL) x blood volume processed (L) x collection efficiency (fraction) / patient weight (kg).
Pearls and pitfalls
- A minimum of 2 x10^6 CD34+ cells/kg is generally required for autologous engraftment; 5 x10^6/kg is often used as an optimal target.