ToolsCalculators
Naloxone continuous infusion dosing
Naloxone continuous infusion dosing
Effective bolus dose (dose that reversed respiratory depression)
mg
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When to use
- Maintaining reversal in opioid overdose with a long-acting or sustained-release opioid after an effective bolus.
Formula
Hourly infusion = two-thirds of the naloxone bolus (mg) that restored adequate ventilation. Titrate to respiratory rate.
Pearls and pitfalls
- Watch for recurrent sedation as the drip is weaned, and for withdrawal if over-titrated.