ToolsCalculators
Myelofibrosis Secondary to PV and ET Prognostic Model (MYSEC-PM)
Predicts survival in myelofibrosis secondary to polycythemia vera or essential thrombocythemia.
Myelofibrosis Secondary to PV and ET Prognostic Model (MYSEC-PM)
Age
years
Hemoglobin
Platelet count
x10⁹/L
Circulating blasts
%
CALR-unmutated genotype (includes CALR status unknown)
Constitutional symptoms (fever, night sweats, weight loss >10%)
Complete the fields above to see the result.
When to use
- Predicting survival specifically in secondary (post-polycythemia vera or post-essential thrombocythemia) myelofibrosis, where the primary-myelofibrosis-derived IPSS/DIPSS underperform.
Formula
Score = 0.15×age(yrs) + 2 (if Hb<11 g/dL) + 2 (if circulating blasts ≥3%) + 2 (if CALR-unmutated) + 1 (if platelets<150x10⁹/L) + 1 (if constitutional symptoms). Low <11, intermediate-1 11-<14, intermediate-2 14-<16, high ≥16.
Pearls and pitfalls
- Outperformed IPSS, DIPSS, and DIPSS-plus for survival prediction in the original and validation cohorts of secondary myelofibrosis.