ToolsCalculators
Multiple Myeloma Response Criteria
Classifies treatment response (CR, VGPR, PR, SD, PD) using IMWG uniform response criteria.
Multiple Myeloma Response Criteria
Baseline serum M-protein
g/dL
Current serum M-protein
g/dL
Baseline 24-hour urine M-protein
mg/24h
Current 24-hour urine M-protein
mg/24h
Bone marrow plasma cells
%
Serum immunofixation negative
Urine immunofixation negative
Soft-tissue plasmacytomas resolved (or absent at baseline)
New bone lesions, new/enlarging soft-tissue plasmacytomas, or new hypercalcemia
Complete the fields above to see the result.
When to use
- Grading disease response during or after multiple myeloma treatment for clinical decision-making or trial reporting.
Formula
CR: negative serum/urine immunofixation, resolved plasmacytomas, BM plasma cells <5%. VGPR: ≥90% serum M-protein reduction and urine M-protein <100 mg/24h. PR: ≥50% serum M-protein reduction with ≥90% urine reduction or urine <200 mg/24h. PD: new lesions/hypercalcemia (or ≥25% rise from nadir).
Pearls and pitfalls
- Stringent CR (sCR) additionally requires a normal serum free light chain ratio and absence of clonal cells by immunohistochemistry/flow cytometry.
- For non-secretory myeloma, serum free light chain assays or PET/CT-based criteria are used instead of M-protein.