ToolsCalculators
MASCC risk index for febrile neutropenia
Identifies low-risk febrile neutropenia suitable for oral/outpatient care.
MASCC risk index for febrile neutropenia
Burden of illness (clinical severity)
Systolic blood pressure
Chronic obstructive pulmonary disease
Tumour type / prior fungal infection
Dehydration requiring parenteral fluids
Status at onset of fever
Age
Result26 points
Score >=21: low risk of serious complications; may be a candidate for oral antibiotics and/or outpatient management with careful selection.
- MASCC index (max 26)
- 26
When to use
- Stratifying adults with chemotherapy-induced febrile neutropenia into low vs high risk.
Formula
Add points: burden of illness (none/mild 5, moderate 3, severe 0), no hypotension 5, no COPD 4, solid tumour or no prior fungal infection 4, no dehydration 3, outpatient at fever onset 3, age <60 = 2. Maximum 26; >=21 = low risk.
Pearls and pitfalls
- The burden-of-illness item is a single clinical judgement, not additive across its levels.
- Only low-risk patients without other concerning features should be considered for outpatient therapy.