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Mantle Cell Lymphoma International Prognostic Index (MIPI)
Estimates overall survival in mantle cell lymphoma from age, performance status, LDH, and WBC.
Mantle Cell Lymphoma International Prognostic Index (MIPI)
Age
years
ECOG performance status
LDH ÷ upper limit of normal (ratio)
x ULN
White blood cell count
cells/µL
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When to use
- Estimating overall survival at diagnosis of mantle cell lymphoma using four routinely available variables.
- Risk-stratifying patients before selecting induction intensity or clinical trial eligibility.
Formula
MIPI = 0.03535×age(yrs) + 0.6978×(1 if ECOG≥2 else 0) + 1.367×log10(LDH/ULN) + 0.9393×log10(WBC in cells/µL). Low risk <5.7, intermediate 5.7-<6.2, high ≥6.2.
Pearls and pitfalls
- A biological version (MIPI-b) adds Ki-67 proliferation index and further refines risk in the rituximab era.
- Developed and validated in patients with advanced-stage disease treated in prospective German/European trials.