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Mantle Cell Lymphoma International Prognostic Index (MIPI)
Mantle Cell Lymphoma International Prognostic Index (MIPI)
Age
years
ECOG performance status
LDH ÷ upper limit of normal (ratio)
x ULN
White blood cell count
cells/µL
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When to use
- Estimating overall survival at diagnosis of mantle cell lymphoma using four routinely available variables.
- Risk-stratifying patients before selecting induction intensity or clinical trial eligibility.
Formula
MIPI = 0.03535×age(yrs) + 0.6978×(1 if ECOG≥2 else 0) + 1.367×log10(LDH/ULN) + 0.9393×log10(WBC in cells/µL). Low risk <5.7, intermediate 5.7-<6.2, high ≥6.2.
Pearls and pitfalls
- A biological version (MIPI-b) adds Ki-67 proliferation index and further refines risk in the rituximab era.
- Developed and validated in patients with advanced-stage disease treated in prospective German/European trials.