ToolsCalculators
Manchester Score for Prognosis in Small Cell Lung Cancer
Manchester Score for Prognosis in Small Cell Lung Cancer
Serum LDH above the upper limit of normal
Serum sodium <132 mmol/L
Serum alkaline phosphatase >1.5x the upper limit of normal
Serum bicarbonate <24 mmol/L
Karnofsky performance status <60
Extensive-stage disease
Result0 points
Good prognostic group; reported 2-year survival ~16.2%.
- Prognostic group
- Good
- 2-year survival
- ~16.2%
When to use
- Estimating 2-year survival at diagnosis of small cell lung cancer using routine pretreatment labs, performance status, and stage.
Formula
One point each for: LDH above normal, sodium <132 mmol/L, alkaline phosphatase >1.5x upper limit of normal, bicarbonate <24 mmol/L, Karnofsky performance status <60, and extensive-stage disease. Total 0-6: Good 0-1, Medium 2-3, Poor 4-6.
Pearls and pitfalls
- Derived from Cox regression on 61 candidate pretreatment variables in 407 SCLC patients; stage and performance status remain the dominant contributors.