ToolsCalculators
Lille model for alcoholic hepatitis
Day-7 prediction of steroid non-response in alcoholic hepatitis.
Lille model for alcoholic hepatitis
Age
years
Albumin on day 0
g/L
Bilirubin on day 0
umol/L
Bilirubin on day 7
umol/L
Prothrombin time
seconds
Renal insufficiency (creatinine >1.3 mg/dL / 115 umol/L)
Complete the fields above to see the result.
When to use
- At day 7 of corticosteroid therapy for severe alcoholic hepatitis, to decide whether to continue treatment.
Formula
R = 3.19 - 0.101*age + 0.147*albumin(g/L) + 0.0165*(bilirubin day0 - day7)(umol/L) - 0.206*renal insufficiency - 0.0065*bilirubin day0(umol/L) - 0.0096*PT(s). Lille = exp(-R)/(1+exp(-R)).
Pearls and pitfalls
- Cut-off 0.45 separates responders from non-responders.
- Renal insufficiency scored 1 if creatinine >1.3 mg/dL (115 umol/L).