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Hypothermia Outcome Prediction after ECLS (HOPE) Score

Hypothermia Outcome Prediction after ECLS (HOPE) Score
Sex
Age
years
Mechanism of hypothermia
Core temperature at admission
°C
Serum potassium at admission
mmol/L
Duration of CPR before ECLS
minutes
Complete the fields above to see the result.

When to use

  • Estimating survival probability before or during rewarming with extracorporeal life support for accidental hypothermic cardiac arrest.
  • Supplementing a serum potassium-only triage approach with additional admission variables.

Formula

Logit = 2.44 − 1.55×male − 1.95×asphyxia-related mechanism − 0.0191×age − 2.07×log2(potassium in mmol/L) − 0.573×log2(CPR duration in minutes) + 0.937×core temperature (°C) − 0.0247×core temperature². Predicted survival probability = e^logit / (1 + e^logit).

Pearls and pitfalls

  • Outperformed triage based on serum potassium alone in the derivation cohort (AUC 0.90 vs 0.77).
  • Developed from patients who already underwent ECLS rewarming; use cautiously as the sole determinant of candidacy.

References

  1. Pasquier M, Hugli O, Paal P, et al. Hypothermia outcome prediction after extracorporeal life support for hypothermic cardiac arrest patients: The HOPE score. Resuscitation. 2018;126:58-64.