ToolsCalculators
Genetically Inspired Prognostic Scoring System (GIPSS) for Primary Myelofibrosis (PMF)
Purely genetic (karyotype + mutation) survival stratification in primary myelofibrosis.
Genetically Inspired Prognostic Scoring System (GIPSS) for Primary Myelofibrosis (PMF)
Cytogenetic risk category
Absence of type 1/like CALR mutation
ASXL1 mutated
SRSF2 mutated
U2AF1 Q157 mutated
Result0 points
Low risk; reported median overall survival ~26.4 years.
- Risk category
- Low
- Median overall survival
- 26.4 years
When to use
- Estimating survival in primary myelofibrosis using cytogenetics and driver/high-molecular-risk mutations alone, e.g. when clinical/laboratory data for MIPSS70/DIPSS are unavailable.
Formula
Points: very high risk karyotype = 2, unfavourable karyotype = 1 (favourable = 0); absence of type 1/like CALR = 1; ASXL1, SRSF2, or U2AF1Q157 mutated = 1 each. Total 0-6: Low (0), Intermediate-1 (1), Intermediate-2 (2), High (>=3).
Pearls and pitfalls
- Uses only genetic data (no clinical or laboratory variables), simplifying application when marrow cytogenetics and NGS are available.