ToolsCalculators
Graded Prognostic Assessment for Gastrointestinal Cancer (GI-GPA)
Estimates survival in patients with brain metastases from a gastrointestinal cancer.
Graded Prognostic Assessment for Gastrointestinal Cancer (GI-GPA)
Age
Karnofsky Performance Status
Extracranial metastases
Number of brain metastases
Result0.0 points (of 4)
Median survival in the corresponding prognostic stratum ≈ ≈ 3 months.
- Median survival (GI-GPA cohort)
- ≈ 3 months
When to use
- Estimating survival and informing treatment intensity in patients with newly diagnosed brain metastases from a gastrointestinal primary cancer.
Formula
GI-GPA (0-4) = points for age (<60=0.5, ≥60=0) + KPS (<80=0, 80-90=1, 90-100=2) + absence of extracranial metastases (absent=0.5, present=0) + number of brain metastases (1=1, 2-3=0.5, >3=0).
Pearls and pitfalls
- Part of the diagnosis-specific Graded Prognostic Assessment (GPA) family; use the disease-specific version (here, GI-GPA) rather than the original generic GPA for GI primaries.
- Intended to inform, not replace, multidisciplinary discussion of surgery, stereotactic radiosurgery, whole-brain radiotherapy, and systemic therapy.