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Follicular Lymphoma International Prognostic Index (FLIPI)

Prognostic stratification in follicular lymphoma.

Follicular Lymphoma International Prognostic Index (FLIPI)
Age >60 years
Ann Arbor stage III-IV
Haemoglobin <120 g/L
>4 nodal areas involved
Serum LDH above normal
Result0 points

Low risk (10-year overall survival ~71 %).

Risk group
Low risk
10-year overall survival
~71 %

When to use

  • Baseline prognostication in newly diagnosed follicular lymphoma.

Formula

One point each: age >60, Ann Arbor stage III-IV, Hb <120 g/L, >4 nodal areas, elevated LDH. 0-1 low, 2 intermediate, 3-5 high risk.

Pearls and pitfalls

  • Derived before the rituximab era; FLIPI-2 uses different variables but FLIPI remains widely reported.

References

  1. Solal-Celigny P, et al. Blood. 2004;104(5):1258-65.