The Cardiovascular
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Creatinine clearance (Cockcroft–Gault)

Creatinine clearance (Cockcroft–Gault)
Age
years
Sex
Weight
Serum creatinine
Complete the fields above to see the result.

When to use

  • Renal dose adjustment of drugs — notably DOACs, whose labelling and trial dose-reduction criteria were based on Cockcroft–Gault, not eGFR.
  • Assumes stable renal function; unreliable in acute kidney injury.

Formula

CrCl (mL/min) = [(140 − age) × weight (kg)] / (72 × serum creatinine [mg/dL]), × 0.85 if female.

Pearls and pitfalls

  • At the extremes of body habitus the result may mislead; adjusted or ideal body weight is often used in obesity.
  • Because the equation was derived against non-standardised creatinine assays, it can differ meaningfully from CKD-EPI eGFR.

References

  1. Cockcroft DW, Gault MH. Prediction of creatinine clearance from serum creatinine. Nephron. 1976;16(1):31–41.