ToolsCalculators
CNS International Prognostic Index (CNS-IPI)
Risk of CNS relapse in diffuse large B-cell lymphoma.
CNS International Prognostic Index (CNS-IPI)
Age > 60 years
LDH above upper limit of normal
ECOG performance status > 1
Ann Arbor stage III or IV
> 1 extranodal site involved
Kidney and/or adrenal gland involvement
Result0 points
Low risk; approximate 2-year CNS relapse ~0.6 %.
- Risk group
- Low risk
- Approx. 2-year CNS relapse
- ~0.6 %
When to use
- Estimating CNS relapse risk in DLBCL to inform CNS prophylaxis decisions.
Formula
One point each: age > 60, elevated LDH, ECOG > 1, stage III/IV, > 1 extranodal site, kidney/adrenal involvement. Range 0–6; 0–1 low, 2–3 intermediate, 4–6 high.
Pearls and pitfalls
- Kidney/adrenal involvement is weighted as its own factor beyond the standard IPI components.