ToolsCalculators
Asymptomatic (Smoldering) Myeloma Prognosis
Mayo model risk of progression to active myeloma or amyloidosis.
Asymptomatic (Smoldering) Myeloma Prognosis
Serum M-protein ≥3 g/dL
Bone marrow plasma cells ≥10%
Serum free light chain ratio <0.125 or >8
Result0 risk factors
Low risk of progression to symptomatic myeloma or amyloidosis; median time to progression ~10 years.
- Risk category
- Low
- Median time to progression
- ~10 years
When to use
- Stratifying progression risk at diagnosis of smoldering (asymptomatic) multiple myeloma.
Formula
Count of 3 factors: serum M-protein ≥3 g/dL, bone marrow plasma cells ≥10%, serum FLC ratio <0.125 or >8. 1 factor = low risk, 2 = intermediate risk, 3 = high risk.
Pearls and pitfalls
- Derived from a Mayo Clinic cohort of 273 patients with smoldering myeloma followed for progression.
- Later refined by the Mayo 2018 “20/2/20” model and the 2020 IMWG model, which are validated in different cohorts.