The Cardiovascular
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Altitude-adjusted PERC rule

PERC rule using a lower oxygen-saturation threshold for altitude.

Altitude-adjusted PERC rule
Age >= 50 years
Heart rate >= 100 /min
Oxygen saturation < 90% (altitude-adjusted)
Unilateral leg swelling
Hemoptysis
Recent surgery or trauma (within 4 weeks, requiring hospitalization)
Prior PE or DVT
Hormone use (estrogen)
ResultPERC negative

No criteria met: in a patient already judged low pretest probability, PE can be excluded without D-dimer or imaging.

Criteria positive
0

When to use

  • Excluding PE in low-probability patients at high altitude, where a 90% saturation threshold reduces false-positive rule-outs.

Formula

Eight criteria; PERC is negative only if none are present. The altitude-adjusted version uses oxygen saturation <90% (instead of <95%) as the hypoxia criterion.

Pearls and pitfalls

  • PERC only applies after gestalt has already established low pretest probability; it is a rule-out, not a rule-in, tool.

References

  1. Wolf SJ, et al. Am J Emerg Med. 2019;37(1):64-69.
  2. Kline JA, et al. J Thromb Haemost. 2004;2(8):1247-1255.